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Famous People With Triple X Syndrome + Interesting Facts

Famous People With Triple X Syndrome + Interesting Facts

Triple X syndrome, also referred to as 47, XXX or trisomy X, is a condition that is characterized by the presence of an additional X chromosome in each of a female’s cells.

Life Expectancy + Interesting Facts

The syndrome occurs in about 1 in 1000 female births, but, it is estimated that approximately 10 percent of females with the condition are diagnosed in their lifetime.

Based on this figure, around 3,6 million girls and women in the world are estimated to have an extra X chromosome.

Five to 10 girls are born with this syndrome in the US every day, according to the National Institutes of Health.

They have a normal life expectancy.

Symptoms & Characteristics

Common symptoms and characteristics include:

  • frequent urinary tract infections;
  • taller than average height with particularly long legs;
  • heart abnormalities;
  • delayed development of motor skills, like – walking and sitting up;
  • delayed development of language and speech skills;
  • abnormally shaped breastbone;
  • learning disabilities, like – difficulty with understanding or reading (dyslexia);
  • flat feet;
  • weak muscle tone (hypotonia);
  • kidney abnormalities;
  • abnormally curved pinky fingers;
  • seizures (sudden, uncontrolled electrical disturbance in the brain);
  • abdominal pains;
  • constipation;
  • early or late puberty;
  • menstrual irregularities;
  • premature ovarian failure;
  • widely spaced eyes (hypertelorism);
  • vertical folds of skin which cover the inner corners of the eyes;
  • emotional and behavior problems.

Note – some girls may have no symptoms or very mild symptoms which can go undiagnosed.


Kidney Abnormalities

Girls born with the syndrome may have only one kidney or abnormally developed kidneys.


People with this condition may develop a seizure disorder.

Premature Ovarian Failure

It is a loss of normal function of your ovaries before age 40. This can cause infertility. Furthermore, women with the syndrome may have malformed ovaries.

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Mood Problems

Girls with this syndrome may develop depression, anxiety, and attention deficit hyperactivity disorder.

However, these problems might ease as they reach adulthood.


The syndrome is a chromosomal abnormality that is characterized by the presence of an extra X chromosome.

There are a few reasons why this might occur, including:

  • a problem occurred while the embryo was developing – this is called the mosaic form;
  • the father’s sperm was not formed correctly – this is called nondisjunction;
  • the mother’s egg was not formed correctly – this is called nondisjunction.


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The syndrome is generally diagnosed before the delivery of the baby and it is done through:


It is the process of pairing and ordering all the chromosomes of an organism. This is done to detect whether the patient really has the extra X chromosome.

Blood Test

This is done if the healthcare professional notices, upon physical assessment, physical developmental delays.


It is a prenatal test in which a small amount of amniotic fluid is removed from the sac surrounding the developing fetus for testing.

Chorionic Villus Sampling

It is a prenatal test (between the 8th and 10th week of the pregnancy period) in which a sample of chorionic villi is removed from the placenta for testing.

The genetic information in the tissue is then used to find out if a biochemical condition or abnormal gene is present.


There is no cure for the syndrome, however, the treatment is symptomatic and depends on the severity of the signs and symptoms.

Treatment may include:

  • counseling;
  • occupational therapy;
  • physical therapy;
  • developmental therapy;
  • speech therapy.

Important Note

Because girls with the syndrome may be more susceptible to emotional stress, it is essential to make sure that the sufferer has a supportive environment as well.

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List of Famous People With With Triple X Syndrome:

#1 Gemma Ward

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She is an Australian actress, model, and fashion designer who was discovered when she was 14.

Gemma became the youngest to appear on the cover of an American edition of Vogue.

After that, her popularity skyrocketed and she was announced as the new face of renowned brand Calvin Klein.

In 2008, Ward retired from modeling to focus on her budding acting career.

She made her first acting appearance in the film ”The Black Balloon.” Since then Gemma Ward has made her appearance in numerous films, like – Pirates of the Caribbean: On Stranger Tides (2011) and The Strangers.

It is speculated that Gemma has Trisomy X.

#2 Patricia Ann Jacobs

She is a British geneticist and a Professor of Human Genetics at the University of Southampton at Salisbury District Hospital.

In 1993, Patricia was elected as a Fellow of the Royal Society.

She was the first to describe the discovery of an abnormal chromosome in humans — more exactly, the additional X chromosome found in men with Klinefelter syndrome, a chromosomal condition which affects male cognitive and physical development.

In 2011, Patricia Ann received the March of Dimes Prize in Developmental Biology.


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